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X-WR-CALDESC:Events for CRBI
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20260528
DTEND;VALUE=DATE:20260529
DTSTAMP:20260622T165240
CREATED:20260612T204356Z
LAST-MODIFIED:20260612T204356Z
UID:1261-1779926400-1780012799@mycrbi.com
SUMMARY:Visit from Vilnius University
DESCRIPTION:Prof. Daumantas Matulis and Dr. Vytautas Petrauskas as a part of ongoing collaborative discussions that began with the visit of the Lithuanian delegation to York. \nProf. Daumantas Matulis and Dr. Vytautas Petrauskas are from the Department of Biothermodynamics and Drug Design\, Life Sciences Center\, Vilnius University. Their research interests are closely related to biomolecular interactions\, biophysical analysis\, and drug discovery\, so I expect the presentation and discussion to be scientifically engaging. \n— \nDrug Design and Protein–Ligand Binding Database for AI-ML\nProf. Daumantas Matulis\nHead of Department of Biothermodynamics and Drug Design\, Institute of Biotechnology\, Vilnius\nUniversity\, Saulėtekio 7\, Vilnius LT-10257\, Lithuania Email: daumantas.matulis@bti.vu.lt\,\nmatulis@ibt.lt \nAbstract\nDrug molecules exert their effects on disease-associated proteins by binding to them with high\naffinity and selectivity. However\, most small molecules interact only weakly with the majority of\nsites on protein surfaces\, and only a limited number of chemical compounds can selectively and\nstrongly bind to desired sites. In addition\, even minor modifications to a compound’s chemical\nstructure may lead to substantial changes in binding affinity. We designed and investigated the\nbinding of over 1\,000 small-molecule compounds to Carbonic Anhydrase IX\, a transmembrane\nprotein overexpressed in hypoxic solid tumors that promotes metastasis and invasiveness\, and\nsupports cancer cell survival under hypoxic conditions by acidifying the tumor microenvironment.\nWe characterized the thermodynamics of binding of these compounds across the carbonic\nanhydrase enzyme family and identified the determinants of selectivity for CA IX inhibition (1) .\nFluorescent CA IX-selective compounds enabled visualization of CA IX expression in cancer cells\nand tumors and demonstrated efficacy against Neuroblastoma in mouse xenograft models.\nThe data were assembled into the Protein-Ligand Binding Database (PLBD) to apply artificial\nintelligence – machine learning approaches to drug design and are available at https://plbd.org\n(2) . The database contains 8233 binding datasets of 792 compounds interacting with human CA\nisozymes\, Hsp90\, and COVID proteases\, as determined by inhibition of enzymatic activity\, TSA\, ITC\,\nand SPR techniques. The PLBD emphasizes intrinsic parameters and enthalpy\, enhancing the\nunderstanding of reaction mechanisms. The binding data are linked to 138 crystal structures of CA\ncomplexes with ligands. The database has been built using the FAIR data principles to contain the\nraw data with revision and versioning systems. The PLBD led to a deeper understanding of the\nprotein-ligand recognition principles and enabled the achievement of femtomolar affinities in\nsmall-molecule drug design (3) . \nReferences\n1. Matulis\, D. 2019. Carbonic anhydrase as drug target: thermodynamics and structure of inhibitor\nbinding. SPRINGER NATURE.\n2. Lingė\, D.\, M. Gedgaudas\, A. Merkys\, V. Petrauskas\, A. Vaitkus\, A. Grybauskas\, V. Paketurytė\, A.\nZubrienė\, A. Zakšauskas\, A. Mickevičiūtė\, J. Smirnovienė\, L. Baranauskienė\, E. Čapkauskaitė\, V.\nDudutienė\, E. Urniežius\, A. Konovalovas\, E. Kazlauskas\, K. Shubin\, H.B. Schiöth\, W.-Y. Chen\, J.E.\nLadbury\, S. Gražulis\, and D. Matulis. 2023. PLBD: protein–ligand binding database of thermodynamic\nand kinetic intrinsic parameters. Database 2023:baad040\, doi: 10.1093/database/baad040.\n3. Zubrienė\, A.\, M. Kurtenoka\, V. Paketurytė-Latvė\, J. Leitans\, E. Manakova\, M. Žvirblis\, A. Kazaks\, V.\nEimonta\, K. Tars\, S. Gražulis\, V. Petrauskas\, J. Matulienė\, V. Dudutienė\, K. Shubin\, and D. Matulis. 2026.\nAchieving femtomolar affinities in structure-based drug design. Eur. Biophys. J.\, doi: 10.1007/s00249-\n025-01812-5. \n\n 
URL:https://mycrbi.com/event/visit-from-vilnius-university/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20260309T121500
DTEND;TZID=America/Toronto:20260309T131500
DTSTAMP:20260622T165240
CREATED:20260604T162858Z
LAST-MODIFIED:20260604T163355Z
UID:1228-1773058500-1773062100@mycrbi.com
SUMMARY:CRBI/TEPD Seminar
DESCRIPTION:Toby Chan\, MSc.\, York University: “Effect of Non-additivity on High Throughput Screening”. \nLiam Surry\, MSc.\, McMaster University: “A Software Platform for Rapid Drug Adherence and Metabolomic Screening in High-Risk Psychiatric Patients using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry (MSI-CE-MS)”.
URL:https://mycrbi.com/event/crbi-tepd-seminar-11/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20260223T121500
DTEND;TZID=America/Toronto:20260223T131500
DTSTAMP:20260622T165240
CREATED:20260604T162846Z
LAST-MODIFIED:20260604T163059Z
UID:1227-1771848900-1771852500@mycrbi.com
SUMMARY:CRBI/TEPD Seminar
DESCRIPTION:Erica Iantorno\, MSc.\, York University: “Elucidating the Role of Penicillin-Binding Protein 4 in beta-Lactam Resistance Using Hydrogen-Deuterium Exchange Mass Spectrometry”.\nLuca Rustico\, MSc.\, York University: “Developing a Ligase-mediated Platform for the Transcription and Reverse-Transcription of XNA Aptamers”.
URL:https://mycrbi.com/event/crbi-tepd-seminar-10/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20260209T121500
DTEND;TZID=America/Toronto:20260209T131500
DTSTAMP:20260622T165240
CREATED:20260604T162845Z
LAST-MODIFIED:20260604T163100Z
UID:1226-1770639300-1770642900@mycrbi.com
SUMMARY:CRBI/TEPD Seminar
DESCRIPTION:Maryam Jabbarpoor\, PhD.\, York University: “Diastereoselective Synthesis of a-Fluoro-g-Lactams via Difluorocarbene-Triggered Cyclization and Rearrangement”.
URL:https://mycrbi.com/event/crbi-tepd-seminar-9/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20260112T121500
DTEND;TZID=America/Toronto:20260112T131500
DTSTAMP:20260622T165240
CREATED:20260604T162845Z
LAST-MODIFIED:20260604T163100Z
UID:1225-1768220100-1768223700@mycrbi.com
SUMMARY:CRBI/TEPD Seminar
DESCRIPTION:Connor Loupelle\, PhD.\, York University: “Deciphering the hLa-Associated Epitranscriptome: The Human La Protein Modulates Methylation Levels in Transfer RNAs”.\nMinh Thu Vu\, PhD.\, York University: “Development of sensitive aptamer-based lateral flow assay for C-reactive protein detection”.
URL:https://mycrbi.com/event/crbi-tepd-seminar-8/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251201T121500
DTEND;TZID=America/Toronto:20251201T131500
DTSTAMP:20260622T165240
CREATED:20260604T162844Z
LAST-MODIFIED:20260604T163100Z
UID:1224-1764591300-1764594900@mycrbi.com
SUMMARY:CRBI/TEPD Seminar
DESCRIPTION:David Guo\, PhD.\, University of Toronto: “Engineering DNA Origami with Tunable Immunogenicity via Scaffold Sequence Design”.\nShana Alexander\, PhD.\, University of Toronto: “Tuning immunogenicity of DNA-nanoscaffolded immune complexes”.
URL:https://mycrbi.com/event/crbi-tepd-seminar-7/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251117T121500
DTEND;TZID=America/Toronto:20251117T131500
DTSTAMP:20260622T165240
CREATED:20260604T162842Z
LAST-MODIFIED:20260604T163100Z
UID:1223-1763381700-1763385300@mycrbi.com
SUMMARY:CRBI/TEPD Seminar
DESCRIPTION:Huicong Wang\, MSc.\, York University: “Developing a photochemical approach to sequencing m1G in RNA”.\nLuca Di Fabio\, PhD.\, York University: “Performance via Proximity: Studying proximity-induced enhancement of human neutrophil elastase in degradation of extracellular protein targets via DNA aptamer recruitment”.
URL:https://mycrbi.com/event/crbi-tepd-seminar-6/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251103T121500
DTEND;TZID=America/Toronto:20251103T131500
DTSTAMP:20260622T165240
CREATED:20260604T162838Z
LAST-MODIFIED:20260604T163101Z
UID:1222-1762172100-1762175700@mycrbi.com
SUMMARY:CRBI/TEPD Seminar
DESCRIPTION:Dr. Sergey Krylov\, Distinguished Research Professor\, York University: “Bottlenecks in DNA-Encoded Library (DEL) Technology”.
URL:https://mycrbi.com/event/crbi-tepd-seminar-5/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251020T121500
DTEND;TZID=America/Toronto:20251020T131500
DTSTAMP:20260622T165240
CREATED:20260604T162838Z
LAST-MODIFIED:20260604T163101Z
UID:1221-1760962500-1760966100@mycrbi.com
SUMMARY:CRBI/TEPD Seminar
DESCRIPTION:Asghar Arshi\, PhD.\, York University: “Investigating the oncogenic role of circSKA3 in ovarian cancer development as a potential biomarker and therapeutic target”.\nClaire Gillespie\, PhD.\, McMaster University: “The Pharmacokinetics of Oral Tetrahydrocannabinol and Cannabidiol across the spectrum of Glomerular Filtration Rate”.
URL:https://mycrbi.com/event/crbi-tepd-seminar-4/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251006T121500
DTEND;TZID=America/Toronto:20251006T131500
DTSTAMP:20260622T165240
CREATED:20260604T162838Z
LAST-MODIFIED:20260604T163101Z
UID:1220-1759752900-1759756500@mycrbi.com
SUMMARY:CRBI/TEPD Seminar
DESCRIPTION:Ayesha Maqsood\, PhD.\, York University: “Development of a Mass Spectrometry-based Proteomics Method for Clinical Diagnostics”.\nVenita Sitahal\, PhD.\, York University: “Identifying Small Molecule Binding Sites in Proteins using Conventional and Site-Specific HDX-MS”.
URL:https://mycrbi.com/event/crbi-tepd-seminar-3/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250922T121500
DTEND;TZID=America/Toronto:20250922T131500
DTSTAMP:20260622T165240
CREATED:20260604T162837Z
LAST-MODIFIED:20260604T163101Z
UID:1219-1758543300-1758546900@mycrbi.com
SUMMARY:CRBI/TEPD Seminar
DESCRIPTION:Taranjot Kaur\, MSc.\, York University: “Assessment of Cytochrome P450 Function in Individual Cancer Cells Using Cytometry of Reaction Rate Constant (CRRC)”.\nZhiyuan Mao\, MSc.\, York University: “Enhancing ACTIS: Automation and Integration of Mass Spectrometry and Fluorescence Detection”.
URL:https://mycrbi.com/event/crbi-tepd-seminar-2/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250908T121500
DTEND;TZID=America/Toronto:20250908T131500
DTSTAMP:20260622T165240
CREATED:20260604T162835Z
LAST-MODIFIED:20260604T163102Z
UID:1218-1757333700-1757337300@mycrbi.com
SUMMARY:CRBI/TEPD Seminar
DESCRIPTION:Mike Che\, PhD.\, York University: “Development of a Novel Lateral Flow Immunoassay (LFIA) Architecture for machine learning Applications and Incorporating Electrophoresis-Enhanced into fusion antibody-based COVID-19 LFIA for Signal Amplification”.\nQuan Le\, PhD.\, York University: “Determination of Absolute Injection Volume in Capillary Electrophoresis by the Capillary-Volume-Plateau Calibration (CVPC)”.
URL:https://mycrbi.com/event/crbi-tepd-seminar/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250625T080000
DTEND;TZID=America/Toronto:20250626T170000
DTSTAMP:20260622T165240
CREATED:20250721T135945Z
LAST-MODIFIED:20260604T163724Z
UID:1090-1750838400-1750957200@mycrbi.com
SUMMARY:CREATE/CRBI Joint Conference - July 2025
DESCRIPTION:The CREATE Technology-Enhanced Pharmaceutical Discovery (TEPD) and CRBI conference was held on Wednesday June 25th and Thursday June 26th at The Schulich Executive Learning Center\, York University. The conference featured academic\, industrial partner and academic guest speakers.  Students were able to learn from a field experts and connect with their peers and industry partners. The two day event also included student presentations from the CREATE program as well as students from various labs who presented their research.  Two poster sessions were also featured where six travel awards were presented to the most outstanding poster presentations. \nCREATE-CRBI 2025 Conference Agenda
URL:https://mycrbi.com/event/create-crbi-conference-2025/
CATEGORIES:Conferences
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250506T104500
DTEND;TZID=America/Toronto:20250506T120000
DTSTAMP:20260622T165240
CREATED:20250317T132932Z
LAST-MODIFIED:20260604T154805Z
UID:1075-1746528300-1746532800@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar – Dr. Teshager Dagne Associate Professor\, School of Public Policy and Administration\, York University \nDr. Soren D. Frederiksen  Assistant Professor\, School of Public Policy and Administration\, York University
URL:https://mycrbi.com/event/1075/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250415T104500
DTEND;TZID=America/Toronto:20250415T120000
DTSTAMP:20260622T165240
CREATED:20250317T132628Z
LAST-MODIFIED:20260604T154809Z
UID:1073-1744713900-1744718400@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar – Dr. Leo Chou\, Assistant Professor\, Molecular Engineering\, University of Toronto “DNA-Scaffolded Materials for Biomedical Research and Applications”  \n\nDr .Nima Tabatabaei\, Associate Professor\, Mechanical Engineering. York University\n“Molecular-Specific and Label-Free Sensing and Imaging of Biological Samples”\n 
URL:https://mycrbi.com/event/1073/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250401T104500
DTEND;TZID=America/Toronto:20250401T120000
DTSTAMP:20260622T165240
CREATED:20250317T132300Z
LAST-MODIFIED:20260604T154915Z
UID:1071-1743504300-1743508800@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar – Dr. Marios Fokaefs Assistant Professor\, Electrical Engineering & Computer Science\, York University \n“Supporting software engineering tasks in epidemiological research – An AI approach”
URL:https://mycrbi.com/event/1071/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250328T123000
DTEND;TZID=America/Toronto:20250328T133000
DTSTAMP:20260622T165240
CREATED:20250314T181133Z
LAST-MODIFIED:20260604T154923Z
UID:1026-1743165000-1743168600@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI Seminar – Dr. Qili Feng Professor in School of Life Sciences\, South China Normal University\, Guangzhou\, China \nGene transcription regulation by DNA advanced structures \nDNA advanced structures such as G4 and i-motif\, have been found to play important roles in multiple biological processes. A large-scale genomic analysis of distribution and evolution of the DNA secondary structures in 37 representative species revealed that the number\, density and ratios of advanced structures in the genomes gradually increased with evolution and enriched in the upstream regulatory regions of many genes\, particularly transcription factor genes\, suggesting that these DNA structures may have developed into an epigenetic regulation mechanism for gene transcription in genomes. Methylation modification and advanced structures in DNA molecules are two epigenetic regulation mechanisms for gene transcription. We found that the 5mC modification in G4 forming sequences inhibited the folding of the sequences into G4s. Suppression of whole-genome methylation led to a genome-wide increase in the abundance of G4s. Whole-genome bisulfite sequencing (WGBS) and G4 CUT&Tag data from HeLa and K562 cells revealed that the hypomethylated sequences around transcriptional start sites (TSSs) had a much higher abundance of G4s than the hypermethylated sequences\, suggesting a negative relationship between these two epigenetic mechanisms. G4 and i-motif structures were identified in the promoter of the transcription factor gene BmPOUM2\, which regulates the expression of the wing disc cuticle protein gene (BmWCP4) during metamorphosis in Bombyx mori. Disruption or deletion of the G4 and i-motif structures by base mutation\, anti-sense oligonucleotides (ASOs) \, inhibitory ligands or knockout resulted in significant decrease in the activity of the BmPOUM2 promoter. Two transcription factors (BmLARK and BmILF) were was identified by pull-down experiment and proved to specifically bind to the G4 and i-motif structures\, respectively\, and activated the transcription of BmPOUM2.  All the data indicate that DNA advanced structures function as an epigenetic regulation mechanism for gene transcription and participate in regulation of insect development.
URL:https://mycrbi.com/event/1026/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250304T103000
DTEND;TZID=America/Toronto:20250304T120000
DTSTAMP:20260622T165240
CREATED:20250314T185628Z
LAST-MODIFIED:20260604T154928Z
UID:1069-1741084200-1741089600@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar – Dr. Brian Kim\, Assistant Professor Chemistry\, York University \nNew Frontiers in CRISPR Technologies and Applications
URL:https://mycrbi.com/event/1069/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250204T103000
DTEND;TZID=America/Toronto:20250204T120000
DTSTAMP:20260622T165240
CREATED:20250314T185501Z
LAST-MODIFIED:20260604T154937Z
UID:1067-1738665000-1738670400@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar – Dr. Christo El Morr\, Professor School of Health Policy & Management\, York University \nDr. Rachel da Silveira Gorman\, Associate Professor School of Health Policy & Management\, York University \nAI and Disability Justice: “Decolonizing AI through community engagement and co-design
URL:https://mycrbi.com/event/1067/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250121T103000
DTEND;TZID=America/Toronto:20250121T120000
DTSTAMP:20260622T165240
CREATED:20250314T185117Z
LAST-MODIFIED:20260604T154944Z
UID:1065-1737455400-1737460800@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar – Dr. Sebastian Magierowski\, Associate Professor Electrical Engineering and Computer Science\, York University \nA Chip Designer’s Tour Across Virus Detection Land
URL:https://mycrbi.com/event/1065/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250107T103000
DTEND;TZID=America/Toronto:20250107T120000
DTSTAMP:20260622T165240
CREATED:20250314T184903Z
LAST-MODIFIED:20260604T154951Z
UID:1063-1736245800-1736251200@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar – Dr. Manos Papgelis\, Associate Professor Electrical Engineering and Computer Science\, York University \nMobility-based models for epidemic spreading
URL:https://mycrbi.com/event/1063/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20241210T103000
DTEND;TZID=America/Toronto:20241210T120000
DTSTAMP:20260622T165240
CREATED:20250314T184619Z
LAST-MODIFIED:20260604T154957Z
UID:1061-1733826600-1733832000@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar – Dr. Derek Wilson\, Professor Chemistry\, York University \nA tale of early and late stage anti-covid drug development
URL:https://mycrbi.com/event/1061/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20241126T103000
DTEND;TZID=America/Toronto:20241126T120000
DTSTAMP:20260622T165240
CREATED:20250314T184441Z
LAST-MODIFIED:20260604T155003Z
UID:1059-1732617000-1732622400@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar – Dr. Sergey Krylov\, Distinguished Research Professor\, Chemistry York University \nEnhancing the Reliability of Home Diagnostic Testing: Challenges and Solutions
URL:https://mycrbi.com/event/1059/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240722T080000
DTEND;TZID=America/Toronto:20240722T170000
DTSTAMP:20260622T165240
CREATED:20250311T145112Z
LAST-MODIFIED:20260604T163710Z
UID:978-1721635200-1721667600@mycrbi.com
SUMMARY:CRBI/CREATE Joint Conference - July 2024
DESCRIPTION:CREATE/CRBI joint CONFERENCE JULY 2024\n  \nThe CREATE Technology-Enhanced Pharmaceutical Discovery (TEPD) and CRBI conference was held at York University on Monday July 22nd and Tuesday July 23rd.  Day one featured academic\, industrial partner and pharmaceutical guest speakers.  Students were able to learn from field experts and connect with their peers and industry partners. Day two featured a presentation from Innovation York on Intellectual Property which provided students and other attendees with a broader understanding on this important topic .  The two day event included student presentations from CREATE as well as students from various labs in Chemistry and Biology who presented their research.
URL:https://mycrbi.com/event/978/
CATEGORIES:Conferences
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240625T103000
DTEND;TZID=America/Toronto:20240625T120000
DTSTAMP:20260622T165240
CREATED:20250314T183631Z
LAST-MODIFIED:20260604T155010Z
UID:1054-1719311400-1719316800@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar – Dr. Darius Rackus\, Assistant Professor\, Dept. of Chemistry\, TMU \nMicrofluidic tools for determining disease immunity
URL:https://mycrbi.com/event/1054/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240611T103000
DTEND;TZID=America/Toronto:20240611T120000
DTSTAMP:20260622T165240
CREATED:20250314T183525Z
LAST-MODIFIED:20260604T155014Z
UID:1052-1718101800-1718107200@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar -Dr.Laleh Seyyed-Kalantari\, Assistant Professor\, Dept of Electrical Engineering & Computer Science York University \nFair generative AI in the era of foundation models \nDr. R. Shayna Rosenbaum\, Professor\, Department of Phycology\, York University \nAssessing and improving engagement in protective behaviours during COVID-19
URL:https://mycrbi.com/event/1052/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240528T103000
DTEND;TZID=America/Toronto:20240528T120000
DTSTAMP:20260622T165240
CREATED:20250314T183239Z
LAST-MODIFIED:20260604T155018Z
UID:1050-1716892200-1716897600@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar – Dr. Jennifer Chen\, Associate Professor\, Chemistry\, York University \nNanocrystals and their assemblies for sensing and imaging
URL:https://mycrbi.com/event/1050/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240514T103000
DTEND;TZID=America/Toronto:20240514T120000
DTSTAMP:20260622T165240
CREATED:20250314T183131Z
LAST-MODIFIED:20260604T155021Z
UID:1048-1715682600-1715688000@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:  \nCRBI/CIRC Seminar – Dr. Alvine Boaye Belle\, Assistant Professor\, \, Dept of Electrical Engineering & Computer Science York University \nHumanity 101 for cyber-physical systems
URL:https://mycrbi.com/event/1048/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T133000
DTEND;TZID=America/Toronto:20240425T143000
DTSTAMP:20260622T165240
CREATED:20250312T184836Z
LAST-MODIFIED:20260604T155025Z
UID:985-1714051800-1714055400@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI Seminar – Dr. Martin Schmeing\, McGill University Thursday April 25th 2024 \nBiosynthesis and use of the most interesting polymer you didn’t know existed \nAbstract: \n \nCyanophycin is a natural product polymer with a poly-aspartate backbone and arginines linked to each Asp side chain. Used in bacteria for storage of fixed nitrogen\, carbon and energy\, long chains of cyanophycin coalesce into inert\, membrane-less granules which can occupy most of the volume of a cell. Cyanophycin has a variety of potential green industrial and biomedical applications. Cyanophycin is made by cyanophycin synthetase 1 or 2 through ATP-dependent polymerization of Asp and Arg\, or β-Asp-Arg\, respectively. It is degraded into dipeptides by specialized exo-cyanophycinases\, and these dipeptidase are hydrolyzed into free amino acids by nonspecific isoaspartyl dipeptidases. I will share highlights of our structural and functional studies of cyanophycin biosynthesis and degradation\, which led to surprising discoveries: Our structures and biochemical assays of the cyanophycin synthetase 1 revealed it to be a remarkable\, multi-domain\, multi-functional biosynthetic machine and uncovered a hidden hydrolytic active site that is crucial for rapid biosynthesis. We also showed that cyanophycin synthetase 2 can assume several elegant architectures that influence its synthetic activity. Further\, we discovered and characterized a novel\, large family of isoaspartyl dipeptidases dedicated to cyanophycin metabolism\, which allows the human pathogen Pseudomonas aeruginosa to use β-Asp-Arg as a sole carbon source\, and as good a sole nitrogen source as ammonium. Bioinformatics results underscore how common it is for bacteria to be cyanophycin producers or scavengers\, much more so than currently appreciated. 
URL:https://mycrbi.com/event/985/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240423T103000
DTEND;TZID=America/Toronto:20240423T120000
DTSTAMP:20260622T165240
CREATED:20250314T183010Z
LAST-MODIFIED:20260604T155029Z
UID:1046-1713868200-1713873600@mycrbi.com
SUMMARY:CRBI/CIRC Seminar
DESCRIPTION:CRBI/CIRC Seminar – Dr. Sebastian Magierowski\, Associate Professor\, Dept of Electrical Engineering & Computer Science York University \nSequencing on Silicon
URL:https://mycrbi.com/event/1046/
CATEGORIES:Seminars
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END:VCALENDAR