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X-WR-CALDESC:Events for CRBI
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DTSTART:20220313T070000
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DTSTART:20221106T060000
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240625T103000
DTEND;TZID=America/Toronto:20240625T120000
DTSTAMP:20260508T101207
CREATED:20250314T183631Z
LAST-MODIFIED:20250314T183631Z
UID:1054-1719311400-1719316800@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI/CIRC Seminar – Dr. Darius Rackus\, Assistant Professor\, Dept. of Chemistry\, TMU \nMicrofluidic tools for determining disease immunity
URL:https://mycrbi.com/event/1054/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240611T103000
DTEND;TZID=America/Toronto:20240611T120000
DTSTAMP:20260508T101207
CREATED:20250314T183525Z
LAST-MODIFIED:20250314T183525Z
UID:1052-1718101800-1718107200@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI/CIRC Seminar -Dr.Laleh Seyyed-Kalantari\, Assistant Professor\, Dept of Electrical Engineering & Computer Science York University \nFair generative AI in the era of foundation models \nDr. R. Shayna Rosenbaum\, Professor\, Department of Phycology\, York University \nAssessing and improving engagement in protective behaviours during COVID-19
URL:https://mycrbi.com/event/1052/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240528T103000
DTEND;TZID=America/Toronto:20240528T120000
DTSTAMP:20260508T101207
CREATED:20250314T183239Z
LAST-MODIFIED:20250314T183239Z
UID:1050-1716892200-1716897600@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI/CIRC Seminar – Dr. Jennifer Chen\, Associate Professor\, Chemistry\, York University \nNanocrystals and their assemblies for sensing and imaging
URL:https://mycrbi.com/event/1050/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240514T103000
DTEND;TZID=America/Toronto:20240514T120000
DTSTAMP:20260508T101207
CREATED:20250314T183131Z
LAST-MODIFIED:20250314T184104Z
UID:1048-1715682600-1715688000@mycrbi.com
SUMMARY:
DESCRIPTION:  \nCRBI/CIRC Seminar – Dr. Alvine Boaye Belle\, Assistant Professor\, \, Dept of Electrical Engineering & Computer Science York University \nHumanity 101 for cyber-physical systems
URL:https://mycrbi.com/event/1048/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T133000
DTEND;TZID=America/Toronto:20240425T143000
DTSTAMP:20260508T101207
CREATED:20250312T184836Z
LAST-MODIFIED:20250312T184836Z
UID:985-1714051800-1714055400@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI Seminar – Dr. Martin Schmeing\, McGill University Thursday April 25th 2024 \nBiosynthesis and use of the most interesting polymer you didn’t know existed \nAbstract: \n \nCyanophycin is a natural product polymer with a poly-aspartate backbone and arginines linked to each Asp side chain. Used in bacteria for storage of fixed nitrogen\, carbon and energy\, long chains of cyanophycin coalesce into inert\, membrane-less granules which can occupy most of the volume of a cell. Cyanophycin has a variety of potential green industrial and biomedical applications. Cyanophycin is made by cyanophycin synthetase 1 or 2 through ATP-dependent polymerization of Asp and Arg\, or β-Asp-Arg\, respectively. It is degraded into dipeptides by specialized exo-cyanophycinases\, and these dipeptidase are hydrolyzed into free amino acids by nonspecific isoaspartyl dipeptidases. I will share highlights of our structural and functional studies of cyanophycin biosynthesis and degradation\, which led to surprising discoveries: Our structures and biochemical assays of the cyanophycin synthetase 1 revealed it to be a remarkable\, multi-domain\, multi-functional biosynthetic machine and uncovered a hidden hydrolytic active site that is crucial for rapid biosynthesis. We also showed that cyanophycin synthetase 2 can assume several elegant architectures that influence its synthetic activity. Further\, we discovered and characterized a novel\, large family of isoaspartyl dipeptidases dedicated to cyanophycin metabolism\, which allows the human pathogen Pseudomonas aeruginosa to use β-Asp-Arg as a sole carbon source\, and as good a sole nitrogen source as ammonium. Bioinformatics results underscore how common it is for bacteria to be cyanophycin producers or scavengers\, much more so than currently appreciated. 
URL:https://mycrbi.com/event/985/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240423T103000
DTEND;TZID=America/Toronto:20240423T120000
DTSTAMP:20260508T101207
CREATED:20250314T183010Z
LAST-MODIFIED:20250314T183010Z
UID:1046-1713868200-1713873600@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI/CIRC Seminar – Dr. Sebastian Magierowski\, Associate Professor\, Dept of Electrical Engineering & Computer Science York University \nSequencing on Silicon
URL:https://mycrbi.com/event/1046/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240409T080000
DTEND;TZID=America/Toronto:20240409T170000
DTSTAMP:20260508T101207
CREATED:20250314T182827Z
LAST-MODIFIED:20250314T182827Z
UID:1044-1712649600-1712682000@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI/CIRC Seminar – Dr. Derek Wilson\, Professor Department of Chemistry \nUnderstanding COVID vaccine efficacy on the molecular level
URL:https://mycrbi.com/event/1044/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240326T103000
DTEND;TZID=America/Toronto:20240326T120000
DTSTAMP:20260508T101207
CREATED:20250314T182713Z
LAST-MODIFIED:20250314T182713Z
UID:1042-1711449000-1711454400@mycrbi.com
SUMMARY:
DESCRIPTION:  \nCRBI/CIRC Seminar – Dr. Pouya Rezai\, Associate Professor\, Dept. of Mechanical Engineering\, Lassonde School of Engineering \nFunctional Materials Integrated with Microfluidics for Sample Preparation and Detection of Pathogens and Contaminants in Fluids
URL:https://mycrbi.com/event/1042/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240312T103000
DTEND;TZID=America/Toronto:20240312T120000
DTSTAMP:20260508T101207
CREATED:20250314T182601Z
LAST-MODIFIED:20250314T182601Z
UID:1040-1710239400-1710244800@mycrbi.com
SUMMARY:
DESCRIPTION:  \nCRBI/CIRC Seminar – Dr. Nima Tabatabaei\, Associate Professor Department of Mechanical Engineering York University \nHarnessing Light for Molecular-Specific Sensing and Imaging of Biological Samples
URL:https://mycrbi.com/event/1040/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240220T103000
DTEND;TZID=America/Toronto:20240220T120000
DTSTAMP:20260508T101207
CREATED:20250314T182338Z
LAST-MODIFIED:20250314T182338Z
UID:1038-1708425000-1708430400@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI/CIRC Seminar – Dr. Ebrahim Ghafar-Zadeh\, Associate Professor\, Dept. of Electrical Engineering & Computer Science\, Lassonde School of Engineering \nElectronic Point-of-Care Diagnostics: Recent Advances and Future Prospects \nBill Kim\, Assistant Professor\, Dept. of Chemistry\, York University \nNext-generation Genome Editing: Technology and Applications
URL:https://mycrbi.com/event/1038/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240213T103000
DTEND;TZID=America/Toronto:20240213T113000
DTSTAMP:20260508T101207
CREATED:20250314T181929Z
LAST-MODIFIED:20250314T181929Z
UID:1036-1707820200-1707823800@mycrbi.com
SUMMARY:
DESCRIPTION:  \nCRBI/CIRC Seminar – Dr. Jude Dzevela Kong\, Associate Professor\, Department of Mathematics\, York University \nHarnessing Light for Molecular-Specific Sensing and Imaging of Biological Samples
URL:https://mycrbi.com/event/1036/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240123T103000
DTEND;TZID=America/Toronto:20240123T120000
DTSTAMP:20260508T101207
CREATED:20250314T181757Z
LAST-MODIFIED:20250314T182446Z
UID:1034-1706005800-1706011200@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI/CIRC Seminar – Dr. Jianhong Wu\, Professor Dept. of Mathematics\, York University \nIdentifying contact mixing patterns in respond to public health interventions and behavioral changes
URL:https://mycrbi.com/event/1034/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240109T103000
DTEND;TZID=America/Toronto:20240109T120000
DTSTAMP:20260508T101207
CREATED:20250314T181613Z
LAST-MODIFIED:20250314T182415Z
UID:1032-1704796200-1704801600@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI/CIRC Seminar – \nDr. Seyed M Moghadas\, Professor\, Dept of Mathematics\, York University \nCOVID-19 Quarantine and Testing Strategies for Preventing Onward Transmission \nJason Kindrachuk\, Associate Professor\, Medical Microbiology & Infectious Diseases\, University of Manitoba \nInvestigating emerging zoonotic virus circulation and spillover at the human-wildlife interface in diverse global settings – increasing preparedness and response capacities
URL:https://mycrbi.com/event/1032/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231218T103000
DTEND;TZID=America/Toronto:20231218T113000
DTSTAMP:20260508T101207
CREATED:20250311T151234Z
LAST-MODIFIED:20250311T151514Z
UID:983-1702895400-1702899000@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI Seminar – Karen C. Waldron\nDepartment of Chemistry\, Université de Montréal \nCrosslinked proteolytic enzymes for microscale proteomics applications \nProteolytic enzymes are routinely used to cleave the potentially thousands of proteins in a biological sample into smaller\, more manageable peptide fragments. This facilitates their separation and identification by nano-HPLC\, capillary electrophoresis (CE) and/or mass spectrometry (MS). This process\, called peptide mapping\, is one of the steps used in the workflow for identifying\, quantifying\, characterizing or probing the function of proteins in the vast field of proteomics\, specifically “bottom-up” proteomics. Insoluble proteolytic enzymes (i.e.\, trypsin\, chymotrypsin\, pepsin\, Lys-C\, Asp-N\, etc.) offer several benefits such as limited autolysis\, reusability and rapid digestion because high enzyme-to-substrate ratios can be used. The added advantage of adaptability to microreactor formats and microfluidic platforms comes from using glutaraldehyde (GA) to crosslink enzymes and render them insoluble instead of immobilizing them on solid-phase supports. In 2004 we reported a multi-step GA-crosslinking procedure for trypsin and compared its specific activity and peptide maps to trypsin immobilized onto GA-functionalized glass beads. The procedure was later adapted for chymotrypsin to digest nanomolar concentrations of fluorescently labelled protein substrate with peptide mapping by CE laser-induced fluorescence (LIF) detection. A GA-chymotrypsin microreactor was fabricated in a capillary column by programing reagent delivery in a CE instrument. Despite the ease in making GA-crosslinked trypsin and chymotrypsin “particles”\, their re-use for multiple digestions has been problematic. Our successes and setbacks will be discussed\, as well as our efforts to improve the robustness of the crosslinked enzymes using a Design-ofExperiments (DOE) approach to investigate the experimental parameters in our multi-step crosslinking method.
URL:https://mycrbi.com/event/983/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20230711
DTEND;VALUE=DATE:20230712
DTSTAMP:20260508T101207
CREATED:20250311T144601Z
LAST-MODIFIED:20250311T144601Z
UID:976-1689033600-1689119999@mycrbi.com
SUMMARY:
DESCRIPTION:CREATE/CRBI joint CONFERENCE JULY 2023 \nThe joint CREATE Technology-Enhanced Pharmaceutical Discovery (TEPD) and CRBI conference was held at York University on Monday July 10th and Tuesday July 11th .  Day one included workshops featuring guest speakers from Eurofins\, Gilead and GSK. Students were able to learn from industry experts and connect with their peers. Day two featured student presentations from various labs in Chemistry and Biology as well as students from the Centre for Research on Biomolecular Interactions (CRBI) lab. \n 
URL:https://mycrbi.com/event/976/
CATEGORIES:Conferences
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230307T080000
DTEND;TZID=America/Toronto:20230307T170000
DTSTAMP:20260508T101207
CREATED:20230307T124700Z
LAST-MODIFIED:20250215T150057Z
UID:853-1678176000-1678208400@mycrbi.com
SUMMARY:CRBI seminar - Philip Britz-McKibbin
DESCRIPTION:Abstract: \n  \nNew advances in analytical chemistry for large-scale epidemiological studies: Insights into nutrition and smoke exposures for global health \n  \nA suboptimal diet and tobacco smoking are two leading modifiable risk factors in chronic disease burden globally that are typically evaluated using questionnaires by epidemiologists despite being prone to bias and misreporting. This presentation will focus on new advances in mass spectrometry (MS)-based metabolomics research when coupled to capillary electrophoresis (CE) that may allow for more reliable assessment of exposures and their health impacts in large-scale epidemiological studies. A capillary electrophoresis assay for surveillance of iodine deficiency in the Canadian population will first be presented. This work revealed differences in iodine nutrition and exposures to environmental iodine uptake inhibitors in four different regions across Canada. Also\, recent developments to expand CE-MS techniques for untargeted lipid profiling when using nonaqueous conditions will be discussed. This approach was used to identify specific circulating lipids associated with omega-3 index status\, including biomonitoring changes following high-dose fish oil supplementation. Lastly\, I will present a new approach for biochemical verification of tobacco smoke exposures in various countries at different socioeconomic status in support of global health and chronic disease prevention. Stratification of fast from slower nicotine metabolizers offers a unique way to better assess the true hazards from tobacco smoking in diverse populations.
URL:https://mycrbi.com/event/crbi-seminar-philip-britz-mckibbin/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230201T140000
DTEND;TZID=America/Toronto:20230201T150000
DTSTAMP:20260508T101207
CREATED:20230127T230951Z
LAST-MODIFIED:20230127T230951Z
UID:850-1675260000-1675263600@mycrbi.com
SUMMARY:CRBI seminar - Dr. Leo Chou
DESCRIPTION:
URL:https://mycrbi.com/event/crbi-seminar-dr-leo-chou/
LOCATION:Life Sciences Buliding (LSB) 107
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230201T100000
DTEND;TZID=America/Toronto:20230201T100000
DTSTAMP:20260508T101207
CREATED:20250314T181321Z
LAST-MODIFIED:20250314T181321Z
UID:1030-1675245600-1675245600@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI Seminar – Dr. Leo Chou\, Professor\, University of Toronto
URL:https://mycrbi.com/event/1030/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230118T130000
DTEND;TZID=America/Toronto:20230118T140000
DTSTAMP:20260508T101207
CREATED:20230117T133708Z
LAST-MODIFIED:20230117T133708Z
UID:831-1674046800-1674050400@mycrbi.com
SUMMARY:In person seminar with Dr. Simchi
DESCRIPTION:
URL:https://mycrbi.com/event/in-person-seminar-with-dr-simchi/
LOCATION:Life Sciences Buliding (LSB) 107
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230118T100000
DTEND;TZID=America/Toronto:20230118T110000
DTSTAMP:20260508T101207
CREATED:20250314T181226Z
LAST-MODIFIED:20250314T181226Z
UID:1028-1674036000-1674039600@mycrbi.com
SUMMARY:
DESCRIPTION:  \nCRBI Seminar – Dr. Simchi\, Professor\, Fraunhofer Institute
URL:https://mycrbi.com/event/1028/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221212T140000
DTEND;TZID=America/Toronto:20221212T150000
DTSTAMP:20260508T101207
CREATED:20221210T192051Z
LAST-MODIFIED:20221210T192613Z
UID:818-1670853600-1670857200@mycrbi.com
SUMMARY:In person seminar with Dr. Sachlos
DESCRIPTION:Acute myeloid leukemia is a fatal blood cancer.  The malignant AML blast cells rapidly overwhelm the bone marrow\, disrupting resident hematopoietic stem cells (HSC) and normal blood production and eventually causing death. Treatment involves the administration of DNA-binding chemotherapeutic agents that indiscriminately kill both HSC and progenitors\, leading to myelosuppression and ultimately drug dose attenuation.  Ideally\, drugs should specifically target AML while sparing healthy HSC to reduce potentially lethal myelosuppression side effects and extend the dosing period.  In this talk\, we will discuss the new paradigm of leukemic stem cells and how they can be targeted using differentiation therapy as a novel therapeutic strategy with reduced side effects.  The development of novel stem cell screening platforms able to identify agents that specifically target AML-leukemic stem cells (AML-LSC) while sparing HSC will be explored.  Recent results demonstrating the importance of engineered niche microenvironments to extend the ex vivo lifespan of HSC and AML-LSC will also be presented.  This work sets the foundations high-throughput 3D organoid drug screening using primary human cells extracted from tumours for the development of precision medicine applications.
URL:https://mycrbi.com/event/in-person-seminar-with-dr-sachlos/
LOCATION:Life Sciences Buliding (LSB) 107
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221212T100000
DTEND;TZID=America/Toronto:20221212T110000
DTSTAMP:20260508T101207
CREATED:20250313T183535Z
LAST-MODIFIED:20250313T183535Z
UID:1015-1670839200-1670842800@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI Seminar – Dr. Terry Sachlos\, Associate Professor – Teaching Stream\, York University \nNew paradigm of leukemic stem cells and how they can be targeted using differentiation therapy as novel therapeutic strategy
URL:https://mycrbi.com/event/1015/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221118T110000
DTEND;TZID=America/Toronto:20221118T120000
DTSTAMP:20260508T101207
CREATED:20220928T174704Z
LAST-MODIFIED:20221115T152414Z
UID:766-1668769200-1668772800@mycrbi.com
SUMMARY:In person seminar by Dr. Jennilee Gavina
DESCRIPTION:How can you as an analytical chemist contribute towards developing lifesaving medicines within the pharmaceutical industry? Let’s explore this rewarding career path through learning the whats\, whys\, and hows. First\, we’ll cover some basics about Good Manufacturing Practice (GMP) and regulatory requirements so we can understand what characteristics of a compound need to be controlled and why a wide variety of analytical methodologies are required. Then the fun stuff – how do we apply these methods to manufacturing and when do we need to test? We’ll go over how this all fits together\, with some practical tips and case studies along the way\, and include some insight on the more recent regulatory expectations for nitrosamine control. \nThe event will be followed by a roundtable session with students from 12 pm to 1 pm.
URL:https://mycrbi.com/event/in-person-seminar-by-dr-jennilee-gavina/
LOCATION:Petrie Building – Room 317
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221118T100000
DTEND;TZID=America/Toronto:20221118T110000
DTSTAMP:20260508T101207
CREATED:20250313T183420Z
LAST-MODIFIED:20250313T183420Z
UID:1013-1668765600-1668769200@mycrbi.com
SUMMARY:
DESCRIPTION:  \nCRBI Seminar – Dr. Jennilee Gavina\, Research Scientist\, Gilead \nHow can you as an analytical chemist contribute towards developing life saving medicines within the pharmaceutical industry
URL:https://mycrbi.com/event/1013/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20220707
DTEND;VALUE=DATE:20220708
DTSTAMP:20260508T101207
CREATED:20220928T174956Z
LAST-MODIFIED:20250215T151407Z
UID:775-1657152000-1657238399@mycrbi.com
SUMMARY:CRBI internal conference
DESCRIPTION:
URL:https://mycrbi.com/event/crbi-internal-conference/
LOCATION:Schulich School of Business
CATEGORIES:Conferences
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220504T140000
DTEND;TZID=America/Toronto:20220504T150000
DTSTAMP:20260508T101207
CREATED:20220309T184346Z
LAST-MODIFIED:20220413T200520Z
UID:725-1651672800-1651676400@mycrbi.com
SUMMARY:Dr. Frank Delaglio
DESCRIPTION:Abstract \nProtein therapeutics are a highly successful class of drugs that are used to treat a number of serious and life-threatening conditions such as cancer\, autoimmune disorders\, and infectious diseases including COVID-19.  These therapeutics have numerous critical quality attributes (CQA) that must be evaluated to ensure safety and efficacy\, including that they must adopt and retain the correct structural fold without forming unintended aggregates. Furthermore\, since these therapeutics are manufactured in living cells\, where small variations in growth conditions can have a large therapeutic impact\, analytics for cell growth metabolomics are also needed. This need is even more critical for therapies such as CAR-T\, where the cells themselves are administered directly to the patient. Nuclear magnetic resonance spectroscopy (NMR) is powerful and diverse tool to help meet these measurement needs\, because NMR spectra are sensitive to molecular shape and interactions as well as chemical structure\, and NMR can provide this information at atomic resolution for proteins as well as for the small molecule mixtures comprising the metabolome. Exploiting NMR for these biomanufacturing needs leads to a series of computational challenges which we review\, including spectral reconstruction of incomplete data\, metrics of spectral similarity\, detection and quantification of spectral features\, and spectral analysis of mixtures.
URL:https://mycrbi.com/event/dr-frank-delaglio/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220504T100000
DTEND;TZID=America/Toronto:20220504T110000
DTSTAMP:20260508T101207
CREATED:20250313T183239Z
LAST-MODIFIED:20250313T183239Z
UID:1011-1651658400-1651662000@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI Seminar – Dr. Frank Delaglio\, Professor\, University of Leicester\, UK \nExploiting NMR for Biomanufacturing needs
URL:https://mycrbi.com/event/1011/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220406T140000
DTEND;TZID=America/Toronto:20220406T150000
DTSTAMP:20260508T101207
CREATED:20220307T200735Z
LAST-MODIFIED:20220309T184344Z
UID:648-1649253600-1649257200@mycrbi.com
SUMMARY:Dr. Igor Jurisica
DESCRIPTION:AI is Not Enough: Explainable Biology for Improved Therapies: Integrative computational biology and AI help improving treatment of complex diseases by building explainable models. From systematic data analysis to improved biomarkers\, drug mechanism of action\, and patient selection\, such analyses influence multiple steps of drug discovery pipeline. Data mining\, machine learning\, graph theory and advanced visualization help characterize interactome and drug orphans with accurate predictions\, making disease modeling more comprehensive. Intertwining computational prediction and modeling with biological experiments will lead to more useful findings faster and more economically. Learning Objectives: Participants will learn about the main challenges and opportunities in precision medicine using artificial intelligence\, big data analytics and integrative computational biology workflows
URL:https://mycrbi.com/event/dr-igor-jurisica/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220406T100000
DTEND;TZID=America/Toronto:20220406T110000
DTSTAMP:20260508T101207
CREATED:20250313T184611Z
LAST-MODIFIED:20250313T184611Z
UID:1018-1649239200-1649242800@mycrbi.com
SUMMARY:
DESCRIPTION:CRBI Seminar – Dr. Igor Jurisica\, Medical Biophysics\, University of Toronto \nAi is not Enough: Explainable Biology for Improved Therapies \n 
URL:https://mycrbi.com/event/1018/
CATEGORIES:Seminars
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220302T140000
DTEND;TZID=America/Toronto:20220302T150000
DTSTAMP:20260508T101207
CREATED:20220110T212209Z
LAST-MODIFIED:20220309T184343Z
UID:359-1646229600-1646233200@mycrbi.com
SUMMARY:Prof. Yulia Gerasimova
DESCRIPTION:Abstract: Nucleic acid interrogation with colorimetric and fluorescent DNA probes:  Nucleic acid analysis has benefited from the development of hybridization probes that interrogate nucleic acids in a sequence-specific manner. We have efficiently utilized a split approach for the design of hybridization probes based on deoxyribozymes and aptamers as scaffolds. In split probes\, analyte-recognizing fragment of the probe is divided into two parts. The two parts need to be simultaneously bound to the target for generation of either fluorescent or colorimetric signal. This approach offers such advantages as excellent selectivity\, efficient interrogation of structured nucleic acid sequences\, use of a universal signal reporter\, and (for fluorescent probes) tolerance to inhibitors in complex mixtures (e.g. cell lysates).ÿ A promising reporter system for hybridization analysis is based on light-up aptamers\, among which DNA aptamers are preferable over RNA counterparts due to greater stability and lower synthetic cost. We have studied a recently reported light-up DNA aptamer and discovered its ability to bind and increase fluorescence of otherwise non-fluorescent dyes including commercially available auramine O and crystal violet. Based on mutagenesis\, spectroscopic and molecular simulation data\, we proposed the structure of the aptamer and its dye-binding site. The data can be used in designing aptamer-based probes. Most recently\, we discovered the preferential binding of GelRed (a commercial gel staining dye) to single-stranded oligothymidylate sequences\, which suggests that poly(dT) may exhibit a regular structure\, and may open a route towards designing fluorescent light up sensors. To enable in-field interrogation of nucleic acid targets\, a hybridization assay would benefit for an easy-to-read signal output\, such as a color change.ÿ We took advantage of a peroxidase-like activity of oligonucleotides that have a propensity to fold into a parallel guanine quadruplex structure to develop colorimetric/visual sensing systems. Such systems were used for interrogation of nucleic acid sequences to enable detection and drug-susceptibility testing of bacterial pat
URL:https://mycrbi.com/event/prof-yulia-gerasimova/
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