Abstract Protein therapeutics are a highly successful class of drugs that are used to treat a number of serious and life-threatening conditions such as cancer, autoimmune disorders, and infectious diseases including COVID-19. These therapeutics have numerous critical quality attributes (CQA) that must be evaluated to ensure safety and efficacy, including that they must adopt and …
AI is Not Enough: Explainable Biology for Improved Therapies: Integrative computational biology and AI help improving treatment of complex diseases by building explainable models. From systematic data analysis to improved biomarkers, drug mechanism of action, and patient selection, such analyses influence multiple steps of drug discovery pipeline. Data mining, machine learning, graph theory and advanced …
Abstract: Nucleic acid interrogation with colorimetric and fluorescent DNA probes: Nucleic acid analysis has benefited from the development of hybridization probes that interrogate nucleic acids in a sequence-specific manner. We have efficiently utilized a split approach for the design of hybridization probes based on deoxyribozymes and aptamers as scaffolds. In split probes, analyte-recognizing fragment of …
