Abstract: Scientific discovery is the driving force behind technological and societal progress. It is at the heart of finding new drugs to treat diseases, new materials for clean and sustainable manufacturing and energy production and myriad other innovations. But to deal with many challenges our world is facing, we have to accelerate the pace of discovery. …
Abstract: The birth of biotechnology marked a defining moment in American science that launched a multi-billion-dollar industry built on the concept that enzymes found in nature could be used to improve human health. This relatively simple idea revolutionized medicine by providing the tools need to synthesize, sequence, and manipulate DNA with exquisite precision. The panoply …
Abstract: The birth of biotechnology marked a defining moment in American science that launched a multi-billion-dollar industry built on the concept that enzymes found in nature could be used to improve human health. This relatively simple idea revolutionized medicine by providing the tools need to synthesize, sequence, and manipulate DNA with exquisite precision. The panoply …
Abstract: Nucleic acid interrogation with colorimetric and fluorescent DNA probes: Nucleic acid analysis has benefited from the development of hybridization probes that interrogate nucleic acids in a sequence-specific manner. We have efficiently utilized a split approach for the design of hybridization probes based on deoxyribozymes and aptamers as scaffolds. In split probes, analyte-recognizing fragment of …
AI is Not Enough: Explainable Biology for Improved Therapies: Integrative computational biology and AI help improving treatment of complex diseases by building explainable models. From systematic data analysis to improved biomarkers, drug mechanism of action, and patient selection, such analyses influence multiple steps of drug discovery pipeline. Data mining, machine learning, graph theory and advanced …
