Abstract: Scientific discovery is the driving force behind technological and societal progress. It is at the heart of finding new drugs to treat diseases, new materials for clean and sustainable manufacturing and energy production and myriad other innovations. But to deal with many challenges our world is facing, we have to accelerate the pace of discovery. …
Abstract: The birth of biotechnology marked a defining moment in American science that launched a multi-billion-dollar industry built on the concept that enzymes found in nature could be used to improve human health. This relatively simple idea revolutionized medicine by providing the tools need to synthesize, sequence, and manipulate DNA with exquisite precision. The panoply …
Abstract: The birth of biotechnology marked a defining moment in American science that launched a multi-billion-dollar industry built on the concept that enzymes found in nature could be used to improve human health. This relatively simple idea revolutionized medicine by providing the tools need to synthesize, sequence, and manipulate DNA with exquisite precision. The panoply …
Abstract: Nucleic acid interrogation with colorimetric and fluorescent DNA probes: Nucleic acid analysis has benefited from the development of hybridization probes that interrogate nucleic acids in a sequence-specific manner. We have efficiently utilized a split approach for the design of hybridization probes based on deoxyribozymes and aptamers as scaffolds. In split probes, analyte-recognizing fragment of …
AI is Not Enough: Explainable Biology for Improved Therapies: Integrative computational biology and AI help improving treatment of complex diseases by building explainable models. From systematic data analysis to improved biomarkers, drug mechanism of action, and patient selection, such analyses influence multiple steps of drug discovery pipeline. Data mining, machine learning, graph theory and advanced …
Abstract Protein therapeutics are a highly successful class of drugs that are used to treat a number of serious and life-threatening conditions such as cancer, autoimmune disorders, and infectious diseases including COVID-19. These therapeutics have numerous critical quality attributes (CQA) that must be evaluated to ensure safety and efficacy, including that they must adopt and …
How can you as an analytical chemist contribute towards developing lifesaving medicines within the pharmaceutical industry? Let's explore this rewarding career path through learning the whats, whys, and hows. First, we’ll cover some basics about Good Manufacturing Practice (GMP) and regulatory requirements so we can understand what characteristics of a compound need to be controlled …
Acute myeloid leukemia is a fatal blood cancer. The malignant AML blast cells rapidly overwhelm the bone marrow, disrupting resident hematopoietic stem cells (HSC) and normal blood production and eventually causing death. Treatment involves the administration of DNA-binding chemotherapeutic agents that indiscriminately kill both HSC and progenitors, leading to myelosuppression and ultimately drug dose attenuation. Ideally, drugs should specifically target …
Abstract: New advances in analytical chemistry for large-scale epidemiological studies: Insights into nutrition and smoke exposures for global health A suboptimal diet and tobacco smoking are two leading modifiable risk factors in chronic disease burden globally that are typically evaluated using questionnaires by epidemiologists despite being prone to bias and misreporting. This presentation …
