CRBI Seminar - Yulia Gerasimova, Professor, University of Central Florida Nucleic acid interrogation with colorimetric and fluorescent DNA probes

Abstract: Nucleic acid interrogation with colorimetric and fluorescent DNA probes: Nucleic acid analysis has benefited from the development of hybridization probes that interrogate nucleic acids in a sequence-specific manner. We have efficiently utilized a split approach for the design of hybridization probes based on deoxyribozymes and aptamers as scaffolds. In split probes, analyte-recognizing fragment of …

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CRBI Seminar - Dr. Igor Jurisica, Medical Biophysics, University of Toronto Ai is not Enough: Explainable Biology for Improved Therapies  

AI is Not Enough: Explainable Biology for Improved Therapies: Integrative computational biology and AI help improving treatment of complex diseases by building explainable models. From systematic data analysis to improved biomarkers, drug mechanism of action, and patient selection, such analyses influence multiple steps of drug discovery pipeline. Data mining, machine learning, graph theory and advanced …

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CRBI Seminar - Dr. Frank Delaglio, Professor, University of Leicester, UK Exploiting NMR for Biomanufacturing needs

Abstract Protein therapeutics are a highly successful class of drugs that are used to treat a number of serious and life-threatening conditions such as cancer, autoimmune disorders, and infectious diseases including COVID-19.  These therapeutics have numerous critical quality attributes (CQA) that must be evaluated to ensure safety and efficacy, including that they must adopt and …

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  CRBI Seminar - Dr. Jennilee Gavina, Research Scientist, Gilead How can you as an analytical chemist contribute towards developing life saving medicines within the pharmaceutical industry

How can you as an analytical chemist contribute towards developing lifesaving medicines within the pharmaceutical industry? Let's explore this rewarding career path through learning the whats, whys, and hows. First, we’ll cover some basics about Good Manufacturing Practice (GMP) and regulatory requirements so we can understand what characteristics of a compound need to be controlled …

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CRBI Seminar - Dr. Terry Sachlos, Associate Professor - Teaching Stream, York University New paradigm of leukemic stem cells and how they can be targeted using differentiation therapy as novel therapeutic strategy