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CRBI Seminar - Dr. Terry Sachlos, Associate Professor - Teaching Stream, York University New paradigm of leukemic stem cells and how they can be targeted using differentiation therapy as novel therapeutic strategy
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Acute myeloid leukemia is a fatal blood cancer. The malignant AML blast cells rapidly overwhelm the bone marrow, disrupting resident hematopoietic stem cells (HSC) and normal blood production and eventually causing death. Treatment involves the administration of DNA-binding chemotherapeutic agents that indiscriminately kill both HSC and progenitors, leading to myelosuppression and ultimately drug dose attenuation. Ideally, drugs should specifically target … |
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